- have been playing a retinal stem cell laboratory.
- had never been created in vitro a tissue as complex as a retina.
- It raises the possibility of restoring vision in retinas transplanted.
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We are on track to generate organized tissues that can be used in regenerative medicine researchers RIKEN Center Biology in Kobe (Japan), led by Yoshiki Sasai, embryonic stem cells immersed in a mixture of nutrients. Then, without further assistance specialized cells themselves and organized themselves spontaneously up to three-dimensional shapes.
Sasai and colleagues and roads open to new treatments for eye diseases . Even experts say, raises the possibility of restoring sight to transplanted retinas, generated from own stem cells from a patient.
So far, is believed that stem cells were only used to replace tissue of a muscle or liver, composed of a single cell type. The scientists came to accept that the generation a more complex set of cells was possible only through chemical interactions with other tissues during pregnancy.
dimensional tissue culture
The novelty of this study, published in the journal Nature , is that it has managed to transform embryonic stem cells from a mouse in what is called an optic cup , a three dimensional structure that gives rise to the retina of an eye .
From a patient's stem cells can be generated to be transplanted retinas "We are on track to generate not only different types of cells but organized tissues "that can be used in regenerative medicine, according to Sasai.
Japanese scientists described how stem cells can differentiate and assemble without the chemical and physical influence of other tissues in optic cup can form the characteristic structure of the retina. To do this, scientists used a novel system dimensional tissue culture.
's edition of the magazine also stated that a three-dimensional system equivalent to humans could serve to mimic diseases and test drugs through the use of induced pluripotent stem cells generated from tissues of
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