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find evidence of the influence of nerve cells in the degeneration of the retina

Granada, EFE A group of researchers from the Department Cell Biology, University of Granada has found evidence of the influence of microglial cells in the death of photoreceptor cells, which are responsible for converting light into signals recognizable by neurons.

microglial cells found in the central nervous system and are responsible for removing cellular debris in the eye, today reported Innovapresse, under the Board.

is confirmed one hundred percent this hypothesis would help explain and treat certain retinal degenerative diseases such as retinitis pigmentosa, Usher syndrome, macular degeneration or age related. Michelangelo

Cuadros, who led the project, maintains that if you know the factors related to the programmed death of the photoreceptors' may develop therapeutic strategies to prevent or delay the development of retinal degenerative diseases. "

For this, experts have developed two experimental models: one with live mice those exposed to bright light and another in vitro culture of explants, pieces of retina, also from these rodents.

Researchers have found that microglial cells of the inner layers of the retina of mice issued extensions to the photoreceptor cell nuclei at the very end of exposure to bright light when you start the degeneration of photoreceptors.

Twenty-four hours later there are numerous microglial cells in the region by eliminating degraded cells, and from seventy-two hours, the microglia try to get back to normal, while maintaining the microglial activation if necessary the no new dead cells.

In the explants, retinal fragments, grown in suitable conditions of temperature and nutrients for up to 18 days while maintaining the general characteristics of the retina, analyzed cell viability in culture, which suffered a decline during the first days " probably as a result of the drastic changes experienced by the retina when preparing the explant and placed in a culture medium. "

Subsequently, the overall structure of the retina was kept for two weeks' time during which the experiments were conducted.

were also retinal explants from animals lacking the enzyme PARP-1, involved in DNA repair and related to the activation of microglial function, in which cell death occurred one or two days later in relation to PARP-1 retinas, although the team has yet explain why.

In both cases, researchers found that the decrease in cell viability coincided with an increase in microglial activation confirmed by flow cytometry technique for counting or measuring cell components and properties.

After determining the viability of normal cells, the researchers focused on determining the effect of altering the function of the microglial fragment viability retina.

Currently, this team works in the elimination of microglial cells in retinal explants.

If they remove the microglia get useful information about its influence on retinal degeneration.

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Life Stories First Person - Alicia Benvenuto Staff

WHEN SCHOOL STARTED DISCOVERED WAS SIGHTED Q I was diagnosed with high myopia, and wear sunglasses, THEN IN ADOLESCENCE CONTACT LENSES. Does not tell me any other treatment.

study, I GOT THE PROFESSOR OF HISTORY, served for 14 years my beloved PROFESSION IN SECONDARY SCHOOLS. BUT DURING MY PREGNANCY, ONLY MY SISTER DIED OF CANCER, AND gave me a hormonal imbalance. My son was born very healthy, BUT A I was diagnosed MYOPIC maculopathy, and retired for disability, AS HAD BEEN TO THREE DECIMAL VISION. THE WAY OF ALL STARTED ... PILGRIMAGE OF SPECIALIST SPECIALIST, FIRST SEEKING A CURE, THEN, AND RESIGN, appropriate counseling. I FOUND IN THE DR. MALBRAN FATHER.

ME BUT NOBODY SPOKE OF REHABILITATION, ME, MY ACCOUNT WAS BY ADAPTING MY CUSTOMS AND MY HOUSE TO MY NEW LOCATION. I STARTED TO FIND OUT, SIX YEARS AGO, BY CHANCE, I KNOW GREEN CANE, Q Q HAD STARTED TO USE MAKES FOUR Q GIVEN BY cataracts, lost more than visual acuity.

Q STRIKING TWO YEARS AGO MY WORK SOCIAL REHABILITATION TREATMENT COVER ME, STUDIO POTTERY, GARDEN, BRAILLE, DATA PROCESSING, ORIENTATION AND MOBILITY DID. BRAILLE AND COMPUTER STUDY CURRENTLY IN SCHOOL GATTI, CLERK OF THE GOVERNMENT OF THE CITY OF BS. AS.

THERAPY DID FOR AWHILE, AND LEARNED TO LIVE WITH MY DISABILITY AND ENJOY MY LIFE AS A MEASURE Q TENGO Q SO DO NOT MOURN LOST ... FOLLOWED BY THE LIFE AND ALWAYS WITH A SMILE. FACEBOOK I'M THROUGH WITH CONNECTED PERSONS AND INSTITUTIONS Q DEALING WITH THE PROBLEM OF DISABILITY IN GRAL, AND LOW VISION, Q IS MY PROBLEM, BUT ALSO OF SOLIDARITY SPIRITUALITY, CREO Q SPREADING BECAUSE THIS INFORMATION AND THESE MESSAGES, I CAN BE USEFUL TO SOCIETY. Q I THINK EVERY GRAIN OF SAND Q everyone can contribute, SERVE!

THANK YOU A HUG, ALICIA

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green closer to being regulated

The House passed a bill regulating the use of green cane as an instrument of orientation and mobility for people with low vision. The president of the National Union of the Blind of Uruguay, Gabriel Soto, told 180 that this will help spread the use. "The company is not fully understood the issue of low vision and do not understand why a person uses a green stick, "he said.

Published: April 4, 2011 at 12:22

By: Emiliano Zecca

broadcast Image green cane in Argentina

National Union for the Blind of Uruguay (UNCU) the most important is diffusion. In Article 2, states that "the Executive Branch shall regulate the necessary tools for wider national distribution on the benefits the use of the cane green and its meaning for all Uruguayans. "

The President of the Union of the Blind, Gabriel Soto, said that they " society is not very clear the issue low vision and not understood by why a person uses a green stick. " "So it's important to spread the use to which also the society of account that there are people who see little, but some are. The ideal is that these things were not regulated by law, but is a tool valid in terms of importance, "he said.

The solution is to identify people with low vision with a staff of another color , in this case green. The idea was born in Buenos Aires, city where the use of green cane to identify people with low vision is a law since 2002.

Soto has low vision and regularly use the green cane to get around. UNCU president said the person with low vision is driven more security a blind person. Also the head position is different. "Although we always a tendency to look down, there are looks more direct to faces. Sometimes you wonder why you use a green stick and those who know you wonder how you see " he said.

UNCU President spoke about the internal process that leads him to recognize someone who has low vision and the importance of green cane in the process. He explained that many people see very little, use glasses quite increase, but not considered to have low vision and perhaps themselves are in low vision. "When you start to accept the situation, begins to approach the places where they offer the help . Not before, because it is a duel brave enough to accept that you're losing your vision. The green cane helps us to make that situation is not so brave and we do not directly identify as a blind person, because some see it, "he said.

The project was approved on Wednesday 16 March unanimously in the House of Representatives. The MP for Soriano, Gonzalo Novales, who was presented in November 2008. In the preamble explains that the goal is "to make a contribution seeks to directly benefit the people not blind but with low vision by using green cane international use. "

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